The most common adverse reactions (side effects) with Andexxa were: In another study with 234 patients who experienced a major bleed while taking Xarelto or Eliquis, Andexxa, reversed blood thinning by 93%.The median decrease in anti-Factor Xa activity from baseline was 97% for rivaroxaban (Xarelto) and 92% for apixaban (Eliquis).In a Phase 3 studies in healthy volunteers, Andexxa rapidly and significantly reversed anti-Factor Xa activity within 2 minutes after a bolus injection and sustained these reductions throughout the 2-hour continuous infusion.Andexxa is also approved to reduce the anticoagulant effect of Factor Xa inhibitor Eliquis (apixaban). It neutralizes the anticoagulant effect of Xarelto (rivaroxaban). How does Andexxa work to stop bleeding?Īndexxa works by acting as a trap for oral and injectable Factor Xa inhibitors, binding to the drug to reverse the anticoagulant effect. Vitamin K is often used to reverse bleeding from warfarin but doesn't work for drugs like Xarelto. Coughing up blood or vomit looks like “coffee grounds”.Uncontrollable bleeding or unexpected bruising.Get medical help immediately if you have: You may bruise easily or take longer to stop bleeding from a minor cut. The most common side effect with Xarelto is bleeding. It is given as an intravenous (IV) injection. It is an altered form of the human Factor Xa (10a) molecule, a human enzyme that helps blood to clot and lowers the risk from serious bleeding from Xa inhibitors. Andexxa injection is an antidote that can be used for patients being treated with rivaroxaban (Xarelto) or apixaban (Eliquis) when reversal of anticoagulation (blood thinning) is needed due to life-threatening or uncontrolled bleeding.Īndexxa (coagulation factor Xa), from Portola Pharmaceuticals, is a Factor Xa inhibitor reversal agent approved in 2018.
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